Evidence for a caudate role in aphasia from FDG positron emission tomography
In a recent study correlations between language function and regional glucose metabolism from FDG positron computed tomography were examined. Caudate metabolism correlated with PICA speaking and comprehension factors, as well as BDAE mean writing and reading scores. To identify the language function implicated with caudate metabolism in these eleven patients, twenty subtests making up these two PICA factors and mean BDAE scores were correlated to caudate metabolism. Also a principle components analysis on the twenty subtests identified three factors, only one of which correlated with caudate metabolism. Evidence was found that the caudate has a functional relationship to recognition or motor planning of simple and overlearned materials. This involved simple syntax, low levels of abstraction, identification or sequencing of phonetic and semantic material. This role appeared related to but independent of Broca and frontal lobe function, and may involve the focusing of cortical functions, by allowing two or more regions to interact together.
- Research Organization:
- California Univ., Los Angeles (USA)
- DOE Contract Number:
- AC03-76SF00012
- OSTI ID:
- 6564359
- Report Number(s):
- DOE/SF/00012-T16; ON: DE83005854
- Resource Relation:
- Other Information: Paper copy only, copy does not permit microfiche production
- Country of Publication:
- United States
- Language:
- English
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BRAIN
POSITRON COMPUTED TOMOGRAPHY
GLUCOSE
METABOLISM
PATIENTS
BEHAVIOR
BIOLOGICAL FUNCTIONS
CORRELATIONS
ALDEHYDES
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
FUNCTIONS
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550501 - Metabolism- Tracer Techniques