Effect of sulfur dioxide on pulmonary macrophage endocytosis at rest and during exercise

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · American Review of Respiratory Disease (New York); (USA)

DOI:https://doi.org/10.1164/ajrccm/142.3.655· OSTI ID:6516932

Skornik, W A; Brain, J D ^[1]

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1. Harvard School of Public Health, Boston, MA (USA)

Inhaled SO2 may cause damage by injuring upper airways. To what extent can SO2 also alter pulmonary macrophage function in the parenchyma and what is the impact of exercise We studied the effect of SO2 on pulmonary macrophage endocytosis in resting and in exercising animals by measuring the rates of macrophage endocytosis in situ for 1 h of a test particle of insoluble radioactive colloidal gold (198Au), 1, 24, or 48 h after inhalation exposure to SO2. Resting hamsters exposed for 4 h to 50 ppm SO2 had no significant reduction in macrophage endocytosis compared with air-breathing control hamsters. However, if hamsters were exposed to the same concentration of SO2 while continuously running (40 min at 0.9 km/h), macrophage endocytosis was significantly reduced 1 h after exposure even though the exposure time was only one-sixth as long. Twenty-four hours later, the percentage of gold ingested by pulmonary macrophages remained significantly depressed. By 48 h, the rate had returned to control values. Exercise alone did not affect endocytosis. Hamsters exposed to 50 ppm SO2, with or without exercise, also showed significant reductions in the number of lavaged macrophages. This decrease was greatest and most persistent in the SO2 plus exercise group. These data indicate that even when animals are exposed to water-soluble gases, which are normally removed by the upper airways, exercise can potentiate damage to more peripheral components of the pulmonary defense system such as the macrophage.

• OSTI ID: 6516932
• Journal Information: American Review of Respiratory Disease (New York); (USA), Vol. 142:3; ISSN 0003-0805
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
RESPIRATORY SYSTEM
SENSITIVITY
SULFUR DIOXIDE
TOXICITY
EXERCISE
GOLD 198
HAMSTERS
INHALATION
LAVAGE
MACROPHAGES
TRACER TECHNIQUES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHALCOGENIDES
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
GOLD ISOTOPES
HEAVY NUCLEI
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-ODD NUCLEI
OXIDES
OXYGEN COMPOUNDS
PHAGOCYTES
RADIOISOTOPES
RODENTS
SOMATIC CELLS
SULFUR COMPOUNDS
SULFUR OXIDES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques