Thiamine absorption is not compromised in folate-deficient rats
Thiamine absorption and excretion were assessed in rats with severe folate deficiency (FD) by determining the fate of oral TH-labeled and intravenous UC-labeled thiamine over a 6-h test period. Thiamine status was evaluated in these same rats by measuring transketolase activity levels of blood before (TKA) and after (TPPE) addition of thiamine pyrophosphate to the incubation mixture of the assay procedure. Two additional experiments assessed active transport of thiamine and the effect of dietary succinylsulfathiazole (SST) on TKA and TPPE in rats with moderate FD. Intestinal absorption in general and thiamine absorption in particular and thiamine status were unaltered in rats with severe FD. Inanition associated with severe FD may impair thiamine status. Thiamine absorption by active transport was not compromised in FD, and dietary succinylsulfathiazole did not affect thiamine status.
- Research Organization:
- Univ. of California, Davis (USA)
- OSTI ID:
- 6515259
- Journal Information:
- J. Nutr.; (United States), Vol. 118:11
- Country of Publication:
- United States
- Language:
- English
Similar Records
Turnover of (/sup 14/C)thiamin and activities of thiamin pyrophosphate-dependent enzymes in tissues of mice with Ehrlich ascites carcinoma
Intestinal folate binding protein (FBP) and folate absorption in the suckling rat
Related Subjects
FOLIC ACID
NUTRITIONAL DEFICIENCY
THIAMINE
METABOLISM
TRANSFERASES
ENZYME ACTIVITY
CARBON 14 COMPOUNDS
INTESTINAL ABSORPTION
INTRAVENOUS INJECTION
LIVER
MEMBRANE TRANSPORT
ORAL ADMINISTRATION
RATS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ABSORPTION
AMINES
AMINO ACIDS
ANIMALS
AROMATICS
AZAARENES
AZINES
AZOLES
BODY
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ENZYMES
GLANDS
HEMATINICS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PTERIDINES
PYRIMIDINES
RODENTS
THIAZOLES
UPTAKE
VERTEBRATES
VITAMIN B GROUP
VITAMINS
550501* - Metabolism- Tracer Techniques