Genome shortcut leads to problems
Journal Article
·
· Science (Washington, D.C.); (United States)
Mega YACs (yeast artificial chromosomes), which can carry DNA sequences up to 1.4 million bases long, were anticipated as a major for mapping the human genome. They have been found to have as much as 80% chimerism, however, and contain many deletions and rearrangements. This makes them useless for high-resolution mapping, but they are effective for connecting points over long distances. Mega YACs are still useful for mapping 95% of the human genome.
- OSTI ID:
- 6501890
- Journal Information:
- Science (Washington, D.C.); (United States), Vol. 259:5102; ISSN 0036-8075
- Country of Publication:
- United States
- Language:
- English
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