Blood-ocular and blood-brain barrier function in streptozocin-induced diabetes in rats

Journal Article · Sat Sep 01 00:00:00 EDT 1984 · Arch. Ophthalmol. (Chicago); (United States)

DOI:https://doi.org/10.1001/archopht.1984.01040031108035· OSTI ID:6444329

Maeepea, O; Karlsson, C; Alm, A

Edetic acid labeled with chromium 51 was injected intravenously in normal rats and in rats with streptozocin-induced diabetes. One hour after the injection the animals were killed and the concentrations of edetic acid 51Cr in vitreous body, retina, and brain were determined. No significant difference was observed between the two groups for either tissue. In a second series, a mixture of tritiated 1-glucose and aminohippuric acid tagged with carbon 14 was injected instead of edetic acid. A substantial accumulation of aminohippuric acid 14C compared with tritiated 1-glucose was observed in the vitreous body and the brain of diabetic rats in comparison with the control group. It is concluded that untreated streptozocin-induced diabetes in rats for one to two weeks will not cause a generalized increase in the permeability of the blood-ocular or the blood-brain barriers, but organic acids may accumulate in the vitreous body as well as in the brain as a consequence of reduced outward transport through these barriers.

• Research Organization: Department of Ophthalmology, University Hospital, Uppsala, Sweden
• OSTI ID: 6444329
• Journal Information: Arch. Ophthalmol. (Chicago); (United States), Vol. 102:9
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BLOOD-BRAIN BARRIER
PERMEABILITY
DIABETES MELLITUS
PATHOGENESIS
BIOLOGICAL MODELS
BRAIN
CARBON 14 COMPOUNDS
CHROMIUM 51
EYES
GLUCOSE
HIPPURIC ACID
LABELLED COMPOUNDS
ORGANIC ACIDS
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ALDEHYDES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
BODY AREAS
CARBOHYDRATES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHROMIUM ISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE DISEASES
EVEN-ODD NUCLEI
FACE
HEAD
HEXOSES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METABOLIC DISEASES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RODENTS
SACCHARIDES
SENSE ORGANS
VERTEBRATES
550901* - Pathology- Tracer Techniques