Kinetic analysis of zinc metabolism and its regulation in normal humans

Journal Article · Fri Aug 01 00:00:00 EDT 1986 · Am. J. Physiol.; (United States)

OSTI ID:6411810

Wastney, M E; Aamodt, R L; Rumble, W F; Henkin, R I

Zinc metabolism was studied in 32 normal volunteers after oral or intravenous administration of WVZn. Data were collected from the blood, urine, feces, whole body, and over the liver and thigh regions for 9 mo while the subjects consumed their regular diets (containing 10 mg Zn ion/day) and for an additional 9 mo while the subjects received an exogenous oral supplement of 100 mg Zn ion/day. Data from each subject were fitted by a compartmental model for zinc metabolism that was developed previously for patients with taste and smell dysfunction. These data from normal subjects were used to determine the absorption, distribution, and excretion of zinc and the mass of zinc in erythrocytes, liver, thigh, and whole body. By use of additional data obtained from the present study, the model was refined further such that a large compartment, which was previously determined to contain 90% of the body zinc, was subdivided into two compartments to represent zinc in muscle and bone. When oral zinc intake was increased 11-fold three new sites of regulation of zinc metabolism were identified in addition to the two sites previously defined in patients with taste and smell dysfunction (absorption of zinc from gut and excretion of zinc in urine). The three new sites are exchange of zinc with erythrocytes, release of zinc by muscle, and secretion of zinc into gut. Regulation at these five sites appears to maintain some tissue concentrations of zinc when dietary zinc increases.

• Research Organization: Georgetown Univ. Medical Center, Washington, DC
• OSTI ID: 6411810
• Journal Information: Am. J. Physiol.; (United States), Vol. 251:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ZINC 65
METABOLISM
TISSUE DISTRIBUTION
ZINC CHLORIDES
BLOOD
CHEMICAL REACTION KINETICS
COMPARTMENTS
ERYTHROCYTES
EXCRETION
FECES
LIVER
MAN
MATHEMATICAL MODELS
MUSCLES
PATIENTS
PHYSIOLOGY
SKELETON
TRACE AMOUNTS
URINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD CELLS
BODY
BODY FLUIDS
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KINETICS
MAMMALS
MATERIALS
NUCLEI
ORGANS
PRIMATES
RADIOISOTOPES
REACTION KINETICS
VERTEBRATES
WASTES
ZINC COMPOUNDS
ZINC HALIDES
ZINC ISOTOPES
551001* - Physiological Systems- Tracer Techniques