Inhibition of in vivo histamine metabolism in rats by foodborne and pharmacologic inhibitors of diamine oxidase, histamine N-methyltransferase, and monoamine oxidase
When (/sup 14/C)histamine was administered orally to rats, an average of 80% of the administered radioactivity was recovered in the urine at the end of 24 hr. About 10% of the total dose was excreted via the feces. Analysis of 4-hr urine samples found imidazoleacetic acid to be the predominant metabolite (60.6%), with N tau-methylimidazoleacetic acid (8.6%), N tau-methylhistamine (7.3%), and N-acetylhistamine (4.5%) to be the minor metabolites. Histamine metabolism was inhibited by simultaneous oral administration of aminoguanidine, isoniazid, quinacrine, cadaverine, putrescine, tyramine, and beta-phenylethylamine. The administration of inhibitors resulted in an increased amount of unmetabolized histamine and a decreased amount of metabolites reaching the urine. Pharmacologic inhibitors were found to be more potent and have a longer duration of action than foodborne ones. The inhibitors could potentiate food poisoning caused by histamine by inhibiting its metabolism.
- Research Organization:
- Univ. of Wisconsin, Madison
- OSTI ID:
- 6389474
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Metabolism and disposition of the flame retardant plasticizer, tri-p-cresyl phosphate, in the rat
Metabolism and excretion of 2-ethoxyethanol in the adult male rat
Related Subjects
AMINE OXIDASES
ENZYME INHIBITORS
AMINOTRANSFERASES
CARBON 14 COMPOUNDS
METABOLISM
HISTAMINE
FECES
GUANIDINES
HISTAMINASE
IMIDAZOLES
ORAL ADMINISTRATION
RATS
URINE
AMINES
ANIMALS
AZOLES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBONIC ACID DERIVATIVES
ENZYMES
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NITROGEN TRANSFERASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
RODENTS
TRANSFERASES
VERTEBRATES
WASTES
550501* - Metabolism- Tracer Techniques