Correlation of octanol/water solubility ratios and partition coefficients
Journal Article
·
· Journal of Chemical and Engineering Data
- Univ. of Arizona, Tucson, AZ (United States). Dept. of Pharmaceutical Sciences
The partition coefficient between octanol and water in an important physicochemical parameter for characterizing the lipophilicity or hydrophobicity of a compound and it is used in many fields, especially in the environmental and pharmaceutical sciences. The octanol/water solubility ratio (S{sub o}/S{sub W}) was found to be highly correlated with the octanol/water partition coefficient (K{sub ow}) of 82 pharmaceutically and environmentally relevant compounds. The solubility ratio gives comparable estimates to that of the group contribution (log P(calcd)) method for estimating the partition coefficient of the compounds used in this study.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 63338
- Journal Information:
- Journal of Chemical and Engineering Data, Vol. 40, Issue 3; Other Information: PBD: May-Jun 1995
- Country of Publication:
- United States
- Language:
- English
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