Comparison of the effects of enteral feeding with continuous and intermittent parenteral nutrition on hepatic triglyceride secretion in human beings
Plasma triglyceride turnover was measured during steady-state conditions in 22 postoperative patients. Nine had received nutritional support with an enteral regimen, seven had received an equivalent regimen as continuous parenteral nutrition, and six received the same parenteral regimen as a cyclical infusion. After 5 days of nutritional support, each patient received an intravenous bolus of tritiated glycerol. Plasma radiolabeled triglyceride content was measured during the subsequent 24 hours. The data were analyzed by means of a simple deterministic model of plasma triglyceride kinetics and compared with the results obtained by stochastic analysis. The rates of hepatic triglyceride secretion obtained by deterministic analysis were higher than those obtained by the stochastic approach. However, the mode of delivery of the nutritional regimen did not affect the rate of hepatic triglyceride secretion regardless of the method of analysis. The results suggest that neither complete nutritional bypass of the gastrointestinal tract nor interruption of parenteral nutrition in an attempt to mimic normal eating has any effect on hepatic triglyceride secretion. Any beneficial effect that enteral feeding or cyclical parenteral nutrition may have on liver dysfunction associated with standard parenteral nutrition appears to be unrelated to changes in hepatic triglyceride secretion.
- Research Organization:
- St. James's Univ. Hospital, Leeds (England)
- OSTI ID:
- 6326766
- Journal Information:
- Surgery; (United States), Vol. 105:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
TRIGLYCERIDES
SECRETION
COMPARATIVE EVALUATIONS
GLYCEROL
LIVER
MATHEMATICAL MODELS
NUTRITION
PATIENTS
STOCHASTIC PROCESSES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ALCOHOLS
BODY
DIGESTIVE SYSTEM
ESTERS
GLANDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIPIDS
ORGANIC COMPOUNDS
ORGANS
550501* - Metabolism- Tracer Techniques