Anti-LPS antibodies reduce endotoxemia in whole body Co-60 irradiated primates - A preliminary report

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · Aviation, Space and Environmental Medicine; (USA)

OSTI ID:6320539

Wells, M T; Gaffin, S L; Wessels, B C; Brock-Utne, J G; Jordaan, J P ^[1]

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1. Natal Univ., Durban (South Africa)

A previously established primate model was used to evaluate the role of lipopolysaccharide (LPS, endotoxin) in radiation sickness. Vervet monkeys were Co-60 irradiated with an LD100 exposure and had periodic blood samples taken for the determination of LPS and anti-LPS lgG antibodies and for bacteriological studies. On day 2 postirradiation, primates were treated with either sterile 0.9 percent saline, or equine anti-LPS hyperimmune plasma, or tripotassium-dicitrato-bismuthate (Denol). Results indicate that anti-LPS-treated animals survived significantly longer than both the other groups and, since LPS may cause nausea, vomiting, diarrhea, anorexia, and headaches, it is suggested that Anti-LPS administration may be of value in reducing plasma LPS concentration in humans and improving their performance and survivability. 24 refs.

• OSTI ID: 6320539
• Journal Information: Aviation, Space and Environmental Medicine; (USA), Vol. 61; ISSN 0095-6562
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIBODIES
RADIOSENSITIVITY EFFECTS
MONKEYS
BIOLOGICAL RADIATION EFFECTS
COBALT 60
COSMIC RADIATION
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RADIATION INJURIES
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IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
PRIMATES
RADIATION EFFECTS
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RADIOISOTOPES
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560152* - Radiation Effects on Animals- Animals