Abnormal bone formation induced by implantation of osteosarcoma-derived bone-inducing substance in the X-linked hypophosphatemic mouse

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Bone; (United States)

DOI:https://doi.org/10.1016/8756-3282(85)90006-7· OSTI ID:6294030

Yoshikawa, H; Masuhara, K; Takaoka, K; Ono, K; Tanaka, H; Seino, Y

The X-linked hypophosphatemic mouse (Hyp) has been proposed as a model for the human familial hypophosphatemia (the most common form of vitamin D-resistant rickets). An osteosarcoma-derived bone-inducing substance was subcutaneously implanted into the Hyp mouse. The implant was consistently replaced by cartilage tissue at 2 weeks after implantation. The cartilage matrix seemed to be normal, according to the histological examination, and 35sulphur (TVS) uptake was also normal. Up to 4 weeks after implantation the cartilage matrix was completely replaced by unmineralized bone matrix and hematopoietic bone marrow. Osteoid tissue arising from the implantation of bone inducing substance in the Hyp mouse showed no radiologic or histologic sign of calcification. These findings suggest that the abnormalities of endochondral ossification in the Hyp mouse might be characterized by the failure of mineralization in cartilage and bone matrix. Analysis of the effects of bone-inducing substance on the Hyp mouse may help to give greater insight into the mechanism and treatment of human familial hypophosphatemia.

• Research Organization: Osaka Univ. Medical School, Japan
• OSTI ID: 6294030
• Journal Information: Bone; (United States), Vol. 4
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BONE TISSUES
MINERALIZATION
RICKETS
PATHOGENESIS
SULFUR 35
UPTAKE
CARTILAGE
MICE
OSTEOSARCOMAS
SKELETAL DISEASES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
ISOTOPES
LIGHT NUCLEI
MAMMALS
METABOLIC DISEASES
NEOPLASMS
NUCLEI
RADIOISOTOPES
RODENTS
SARCOMAS
SULFUR ISOTOPES
TISSUES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques