Effect of prostaglandin E/sub 2/ on the small intestine of indomethacin-treated rats

Journal Article · Mon Sep 07 00:00:00 EDT 1987 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(87)90197-4· OSTI ID:6279661

Romain, N; Dandrifosse, G; Forget, P; Lepoint, A

In the present study, the protective effect of PGE/sub 2/ on intestinal damage in indomethacin-treated adult rats was investigated. Ileal integrity was evaluated making use of different biochemical and histological parameters : activities of sucrase, maltase and diamine oxidase; concentrations of DNA, putrescine, spermidine and spermine; incorporation of /sup 3/H-thymidine into DNA; mitotic index and mucosal thickness. Results expressed per g of mucosal weight, showed that : - maltase and diamine oxidase activities as well as DNA, spermidine and spermine concentrations decreased markedly in indomethacin-treated rats when compared to control rats; - the decrease of maltase activity as well as DNA, spermidine and spermine concentration was less pronounced in PGE/sub 2/-treated rats when compared to indomethacin-treated rats; - /sup 3/H-thymidine incorporation into DNA and mitotic index values showed no significant variation in the course of different treatments; - mucosal thickness increased strongly, the PGE/sub 2/-protected rats. The authors suggest that PGE/sub 2/ could protect the rat's intestinal mucosa against the effects of indomethacin through a trophic action on intestinal villi. 15 references, 3 tables.

• Research Organization: Univ. of Liege, Belgium
• OSTI ID: 6279661
• Journal Information: Life Sci.; (United States), Vol. 41:10
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AMINE OXIDASES
ENZYME ACTIVITY
ANTIPYRETICS
TOXICITY
GLYCOSYL HYDROLASES
PROSTAGLANDINS
BIOLOGICAL EFFECTS
DNA
EXPERIMENTAL DATA
MUCOUS MEMBRANES
RATS
SMALL INTESTINE
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
AZINES
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DATA
DIGESTIVE SYSTEM
DRUGS
ENZYMES
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HYDROLASES
INFORMATION
INTESTINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PYRIMIDINES
RIBOSIDES
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques