Effect of inhaled ozone on lung histamine in conscious guinea pigs
The effect of short-term ozone (O/sub 3/) exposure on pulmonary mast cell function was examined. Guinea pigs were continuously exposed to 1.0 ppm O/sub 3/ for 2, 4, and 8 hr. O/sub 3/ exposure produced a significant decrease in lung histamine concentration. Two-hour exposure to O/sub 3/ caused a 22.4 +/- 7.0% decrease in lung histamine concentration compared with controls. Ozone exposures of 4 and 8 hr caused lung histamine concentrations to decrease by 43.7 +/- 7.7 and 49.0 +/- 7.5%, respectively, without significant changes in lung water or protein, or evidence of cytotoxicity. These results suggest that O/sub 3/ or its metabolites affect pulmonary mast cell function by stimulating the release of histamine from the lung.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 6272027
- Journal Information:
- Environ. Res.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HISTAMINE
BIOCHEMICAL REACTION KINETICS
LUNGS
INJURIES
OZONE
TOXICITY
BIOLOGICAL FUNCTIONS
GUINEA PIGS
MAST CELLS
PROTEINS
AMINES
ANIMAL CELLS
ANIMALS
AZOLES
BODY
CONNECTIVE TISSUE CELLS
FUNCTIONS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
KINETICS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology