Scintigraphic determination of the effect of metoclopramide and morphine on small intestinal transit time
To determine if a scintigraphic method could detect pharmacologic changes in small intestinal transit time (SITT), 10 male volunteers were studied at baseline and after intravenously administered metoclopramide (10 mg) and morphine (8 mg). Five of these volunteers were studied with the hydrogen breath test method for comparison. For each of the scintigraphic studies, the volunteers were positioned supine under a large-field-of-view gamma camera after ingesting an isosmotic lactulose solution containing 99mtechnetium-diethylenetriaminepentaacetic acid (DTPA). Data were collected and stored in a computer. Both gastric emptying and SITT were determined. SITT was 81 +/- 11 min (mean +/- S.E.M.; N = 10) during baseline studies, was decreased significantly to 50 +/- 6 min (N = 10; P less than 0.01) after metoclopramide, and was increased significantly to 161 +/- 15 min (N = 8; P less than 0.01) after morphine. Baseline mean values were 86.3 +/- 15 min (N = 15) for the hydrogen breath tests, 47 +/- 8 min (N = 5) for metoclopramide, and 183 +/- 16 min (N = 5) for morphine. For gastric emptying, there was no significant difference in percentage emptying at 1 hr for baseline and metochopramide (82 +/- 5% vs. 88 +/- 4%). Morphine prolonged gastric emptying at 1 hr to 63 +/- 8%. We conclude that the scintigraphic method for measuring SITT permits accurate investigation of the pharmacologic effects on intestinal motility and, in addition, may be a useful research and clinical method for SITT determination.
- Research Organization:
- Hospital of Saint Raphael, New Haven, CT (USA)
- OSTI ID:
- 6270111
- Journal Information:
- Am. J. Physiol. Imag.; (United States), Vol. 3:4
- Country of Publication:
- United States
- Language:
- English
Similar Records
Sulfapyridine appearance in plasma after salicylazosulfapyridine. Another simple measure of intestinal transit
Effect of metoclopramide on normal and delayed gastric emptying in gastroesophageal reflux patients
Related Subjects
MORPHINE
BIOLOGICAL EFFECTS
SMALL INTESTINE
SCINTISCANNING
DTPA
DYNAMIC FUNCTION STUDIES
INTRAVENOUS INJECTION
ISOMERIC NUCLEI
ORGANOMETALLIC COMPOUNDS
TECHNETIUM 99
ALKALOIDS
AMINO ACIDS
ANALGESICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHELATING AGENTS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
GASTROINTESTINAL TRACT
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NARCOTICS
NUCLEI
ODD-EVEN NUCLEI
OPIUM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics