Evaluating the human-health effects of hazardous wastes: Reproduction and development, neurotoxicity, genetic toxicity, and cancer

Technical Report · Tue Jan 01 00:00:00 EST 1991

OSTI ID:6261664

Dyer, R S; Houk, V S; Reiter, L W

Several approaches are available for characterizing potential toxicity of wastes. The paper describes biological tests which are appropriate for identifying waste as neurotoxic, genotoxic, or likely to produce developmental or reproductive effects. The tests recommended are, for neurotoxicity a functional observational battery, coupled with a measure of motor (bodily movement) activity; for genetic toxicity, the 'Ames' test of mutagenicity in Salmonella and a test of clastogenicity (DNA damage); and for developmental and reproductive toxicity, the Chernoff-Kavlock assay and a multigenerational reproductive assay. In addition, the paper identifies several generic factors which must be considered in performing any evaluations of hazardous wastes.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
• OSTI ID: 6261664
• Report Number(s): PB-92-110352/XAB
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HAZARDOUS MATERIALS
TOXICITY
BIOASSAY
CARCINOGENS
DOSE-RESPONSE RELATIONSHIPS
MUTAGENS
NERVOUS SYSTEM
SALMONELLA TYPHIMURIUM
TERATOGENS
WASTES
BACTERIA
MATERIALS
MICROORGANISMS
SALMONELLA
560300* - Chemicals Metabolism & Toxicology