Electrophysiologic evidence of subclinical injury to the posterior columns of the human spinal cord after therapeutic radiation
Spinal somatosensory conduction velocity (SSCV) was indirectly estimated from cerebral evoked potentials in 15 adults who had received therapeutic radiation (RT) (2000-4380 rad) to the thoracic spinal cord during treatment for lung cancer, and in 15 age-matched normal controls. Thirteen of the patients had also received 4400-5500 rad to the supraclavicular fossae. One-way impulse conduction time in the arm, estimated from F-wave latency, was prolonged in the patients as compared to controls (12.0 +/- 1.2 versus 10.4 +/- 1.0 msec; P less than 0.001) but conduction time in the leg was similar in the two groups (22.4 +/- 2.4 versus 22.0 +/- 2.5 msec; P less than 0.1). SSCV was significantly slower in the patient group (37.9 +/- 13.9 versus 54.5 +/- 12.9 m/sec; P less than 0.001) whereas supraspinal latency (cervical cord to cortex) was identical (5.5 +/- 0.9 versus 5.5 +/- 0.8 msec; P less than 0.1). SSCV in the patient group was not related to total RT dose (r . 0.15; P . 0.2), but was correlated with both treatment time and number of fractions (r . 0.49 and 0.43; P . 0.003 and 0.007, respectively). These findings suggest that RT may produce subclinical spinal cord dysfunction even at conventional dosage schedules, and that it may be possible physiologically to monitor the myelopathic effects of RT in individual patients.
- Research Organization:
- Department of Neurology, Stanford University Medical Center, California
- OSTI ID:
- 6239961
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 50:12
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOELECTRICITY
PHYSIOLOGY
NERVE CELLS
BIOLOGICAL RADIATION EFFECTS
RADIOTHERAPY
SIDE EFFECTS
SPINAL CORD
BIOCHEMISTRY
LUNGS
PATIENTS
RADIATION DOSES
ANIMAL CELLS
BIOLOGICAL EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DOSES
ELECTRICITY
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
RESPIRATORY SYSTEM
SOMATIC CELLS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man