Diabetic neuropathy: structural analysis of nerve hydration by Magnetic Resonance Spectroscopy
The water content of the sural nerve of diabetic patients was quantitatively defined by magnetic resonance proton imaging as a putative reflection of activity of the aldose-reductase pathway. Thirty-nine patients were evaluated, comparing group A, symptomatic diabetic men with sensory neuropathy; group B, similarly symptomatic diabetic men treated aldose-reductase inhibition; group C, neurologically asymptomatic diabetic men; and group D, control nondiabetic men. Marked increase in hydration of the sural nerve was seen in more than half of the symptomatic diabetic patients. Two of 11 neurologically asymptomatic diabetics had increased nerve hydration, suggesting a presymptomatic alteration of the nerve. Symptomatic diabetics treated with aldose-reductase inhibitors had normal nerve water levels. Increased level of peripheral nerve water represents a new finding in diabetes mellitus. It seems to be related to aldose-reductase activity, involved in the development of neuropathy, and similar to events that occur in other target tissue in human diabetes.
- Research Organization:
- Univ. of New Mexico, Albuquerque (USA)
- OSTI ID:
- 6206515
- Journal Information:
- JAMA, J. Am. Med. Assoc.; (United States), Vol. 260:19
- Country of Publication:
- United States
- Language:
- English
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NERVES
NUCLEAR MAGNETIC RESONANCE
OXIDOREDUCTASES
BIOCHEMISTRY
BIOELECTRICITY
BIOLOGICAL PATHWAYS
DIABETES MELLITUS
ENZYME ACTIVITY
HISTOLOGY
IN VIVO
PATIENTS
PROTONS
WATER
BARYONS
CHEMISTRY
DISEASES
ELECTRICITY
ELEMENTARY PARTICLES
ENDOCRINE DISEASES
ENZYMES
FERMIONS
HADRONS
HYDROGEN COMPOUNDS
MAGNETIC RESONANCE
METABOLIC DISEASES
NERVOUS SYSTEM
NUCLEONS
OXYGEN COMPOUNDS
RESONANCE
550601* - Medicine- Unsealed Radionuclides in Diagnostics