Evaluation of pulsed fast-atom bombardment ionization for increased sensitivity of tandem mass spectrometry

Journal Article · Sun Jan 15 00:00:00 EST 1989 · Anal. Chem.; (United States)

DOI:https://doi.org/10.1021/ac00177a015· OSTI ID:6190781

Tecklenburg, Jr, R E; Castro, M E; Russell, D H

The use of pulsed valves for performing fast-atom bombardment (FAB) ionization on a sector ion-beam mass spectrometer is described. The objective of this work is to establish new methods for improving the sensitivity of tandem mass spectrometry. This paper deals with the use of pulsed FAB for improving total ion yields as well as signal-to-noise ratios for collision-induced dissociation and laser-ion beam photodissociation. Pulsing the neutral gas pressure used for FAB ionization results in neutral primary beam densities much greater (by a factor of 10) than those obtainable for continuous FAB. This approach yields enhancements for total ion yields and collision-induced dissociation signals by a factor of 15, while larger gains (> 28) are measured for the comparable photodissociation experiment.

• Research Organization: Texas A and M Univ., College Station (USA)
• DOE Contract Number: AS05-82ER13023
• OSTI ID: 6190781
• Journal Information: Anal. Chem.; (United States), Vol. 61:2
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
GLYCEROL
MASS SPECTROSCOPY
ION SOURCES
PERFORMANCE
NEUTRAL BEAM SOURCES
PEPTIDES
EXPERIMENTAL DATA
MASS SPECTROMETERS
PULSE TECHNIQUES
XENON
ALCOHOLS
DATA
ELEMENTS
FLUIDS
GASES
HYDROXY COMPOUNDS
INFORMATION
MEASURING INSTRUMENTS
NONMETALS
NUMERICAL DATA
ORGANIC COMPOUNDS
PROTEINS
RARE GASES
SPECTROMETERS
SPECTROSCOPY
400102* - Chemical & Spectral Procedures