Linkage analysis of early-onset breast and ovarian cancer families, with markers on the long arm of chromosome 17

Journal Article · Thu Apr 01 00:00:00 EST 1993 · American Journal of Human Genetics; (United States)

OSTI ID:6180227

Spurr, N K; Kelsell, D P ^[1]; Black, D M; Solomon, E ^[2]; Murday, V A; Turner, G; Crockford, G P; Cartwright, R A; Bishop, D T ^[3]

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1. Imperial Cancer Research Fund, Hertsfordshire (United Kingdom)
2. Imperial Cancer Research Fund, London (United Kingdom)
3. Imperial Cancer Research Fund, Leeds (United Kingdom)

The authors have conducted linkage analysis in 16 breast cancer families, 13 of which are classified as site-specific breast cancer families and 3 of which are classified as breast-ovary families. Linkage analysis has largely focused on a single extended breast-ovary family. Analysis of all families combined shows significant evidence for linkage to 17q (LOD = 3.63 at [theta] = .0, for linkage to NME1), confirming the observations of Hall et al. and Narod et al. Many families were consistent with linkage, but their limited size and informativeness precluded confirmation of linkage. A putative recombinant in a breast-ovary family suggests that BRCA1 is distal to D17S250. 12 refs., 3 figs.

• OSTI ID: 6180227
• Journal Information: American Journal of Human Genetics; (United States), Vol. 52:4; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HUMAN CHROMOSOME 17
GENETIC MAPPING
MAMMARY GLANDS
NEOPLASMS
OVARIES
RFLPS
UNITED KINGDOM
BODY
CHROMOSOMES
DEVELOPED COUNTRIES
DISEASES
EUROPE
FEMALE GENITALS
GLANDS
GONADS
HUMAN CHROMOSOMES
MAPPING
ORGANS
WESTERN EUROPE
550400* - Genetics