Beta-adrenoceptors in kidney tubules of spontaneously hypertensive and normotensive rats

Journal Article · Mon Jan 13 00:00:00 EST 1986 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(86)90005-6· OSTI ID:6171350

Struyker-Boudier, H A.J.; Vervoort-Peters, L H.T.M.; Rousch, M J.M.; Smits, J F.M.; Thijssen, H H.W.

Beta-adrenoceptor binding characteristics were determined in different fractions of rat kidney tubules using a (/sup 125/Iodo)-(-)-cyanopindolol (ICYP) binding assay. The highest amount of binding sites was found in a fraction containing predominantly distal tubular fragments. In a separate series of experiments the ICYP binding characteristics were compared in whole tubular fractions from spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY) of different ages. The maximum number of binding sites was significantly higher both in young (3 weeks) and adult (14 weeks) SHR when compared to age-matched WKY. These studies showed the presence of beta-adrenoceptor binding sites in rat kidney tubules and support the potential importance of tubular beta-adrenoceptors in the development of spontaneous hypertension and in the mechanism of antihypertensive action of beta-blockers. 35 references, 1 figure, 3 tables.

• Research Organization: Univ. of Limburg, Maastricht, Netherlands
• OSTI ID: 6171350
• Journal Information: Life Sci.; (United States), Vol. 38:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
SYMPATHOMIMETICS
RECEPTORS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL VARIABILITY
COMPARATIVE EVALUATIONS
EXPERIMENTAL DATA
HYPERTENSION
IODINE 125
KIDNEYS
RATS
TRACER TECHNIQUES
VASODILATORS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
DATA
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
REACTION KINETICS
RODENTS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques