Role for Lyt-2+ T cells in resistance to cutaneous leishmaniasis in immunized mice

Journal Article · Wed Mar 15 00:00:00 EST 1989 · J. Immunol.; (United States)

OSTI ID:6171327

Farrell, J P; Muller, I; Louis, J A

The role of Lyt-2+ T cells in immunologic resistance to cutaneous leishmaniasis was analyzed by comparing infection patterns in resistant C57BL/6 mice and susceptible BALB/c mice induced to heal their infections after sub-lethal irradiation or i.v. immunization, with similar mice treated in vivo with anti-Lyt-2 antibodies. Administration of anti-Lyt-2 mAb resulted in a dramatic reduction in the number of lymphoid cells expressing the Lyt-2+ phenotype. Such treatment led to enhanced disease in both resistant C57BL/6 and irradiated BALB/c mice, as assessed by lesion size, but did not affect the capacity of these mice to ultimately resolve their infections. In contrast, anti-Lyt-2 treatment totally blocked the induction of resistance in i.v. immunized mice. These results suggest, that Lyt-2+ T cells may play a role in immunity to a Leishmania major infection and that their relative importance to resistance may depend on how resistance is induced.

• Research Organization: Univ. of Pennsylvania, Philadelphia (USA)
• OSTI ID: 6171327
• Journal Information: J. Immunol.; (United States), Vol. 142:6
• Country of Publication: United States
• Language: English

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560152* - Radiation Effects on Animals- Animals