Urinary excretion of cyclic nucleotides, creatinine prostaglandin E2 and thromboxane B2 from mice exposed to whole-body irradiation from an enhanced neutron field

Technical Report · Wed Jan 01 00:00:00 EST 1986

OSTI ID:6169312

Steel, L K; Rafferty, M A; Wolfe, W W; Egan, J E; Kennedy, D A

Urine volume and excretion of cyclic AMP, cyclic GMP, prostaglandin E2 (PGE2), thromboxane B2 (TxB2) and creatinine were evaluated as potential indicators of radiation damage in mice given 2-5 Gy to the whole body from an enhanced neutron field. In general, urinary cyclic AMP, cyclic GMP, creatinine and urine volumes were positively correlated across time postexposure, for each radiation dose. TxB2 levels positively correlated with urine volume and cyclic AMP excretion only in animals given 2.0Gy. None of these parameters suggests their use as a prognostic indicator of the extent of radiation damage. Urinary excretion of PGE2 was negatively correlated with other urinary parameters. Biphasic increases in urinary PGE2 were also observed. The initial transient elevation 2-3 days postexposure was not correlated with the dose (2-5 Gy). The second elevation of PGE2 excretion occurred at 6-10 days. The magnitude of the latter increase suggests that urinary PGE2 excretion may be a useful indicator of whole-body or kidney exposure to neutron fields.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
• OSTI ID: 6169312
• Report Number(s): AD-A-181788/1/XAB; AFRRI-SR-86-49
• Resource Relation: Other Information: Pub. in International Jnl. of Radiation Biology, Vol. 50, No. 4, 695-715(1986)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
EXCRETION
MICE
BIOLOGICAL RADIATION EFFECTS
NEUTRONS
URINE
RADIOSENSITIZERS
CREATININE
INDICATORS
KIDNEYS
METABOLITES
NUCLEOTIDES
RADIATION INJURIES
VOLUME
ANIMALS
AZOLES
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CLEARANCE
DRUGS
ELEMENTARY PARTICLES
FERMIONS
HADRONS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMINES
INJURIES
MAMMALS
MATERIALS
NUCLEONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATION EFFECTS
RODENTS
VERTEBRATES
WASTES
560152* - Radiation Effects on Animals- Animals