skip to main content

Title: Urinary excretion of cyclic nucleotides, creatinine prostaglandin E2 and thromboxane B2 from mice exposed to whole-body irradiation from an enhanced neutron field

Urine volume and excretion of cyclic AMP, cyclic GMP, prostaglandin E2 (PGE2), thromboxane B2 (TxB2) and creatinine were evaluated as potential indicators of radiation damage in mice given 2-5 Gy to the whole body from an enhanced neutron field. In general, urinary cyclic AMP, cyclic GMP, creatinine and urine volumes were positively correlated across time postexposure, for each radiation dose. TxB2 levels positively correlated with urine volume and cyclic AMP excretion only in animals given 2.0Gy. None of these parameters suggests their use as a prognostic indicator of the extent of radiation damage. Urinary excretion of PGE2 was negatively correlated with other urinary parameters. Biphasic increases in urinary PGE2 were also observed. The initial transient elevation 2-3 days postexposure was not correlated with the dose (2-5 Gy). The second elevation of PGE2 excretion occurred at 6-10 days. The magnitude of the latter increase suggests that urinary PGE2 excretion may be a useful indicator of whole-body or kidney exposure to neutron fields.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
6169312
Report Number(s):
AD-A-181788/1/XAB; AFRRI-SR-86-49
Resource Type:
Technical Report
Resource Relation:
Other Information: Pub. in International Jnl. of Radiation Biology, Vol. 50, No. 4, 695-715(1986)
Research Org:
Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EXCRETION; MICE; BIOLOGICAL RADIATION EFFECTS; NEUTRONS; URINE; RADIOSENSITIZERS; CREATININE; INDICATORS; KIDNEYS; METABOLITES; NUCLEOTIDES; RADIATION INJURIES; VOLUME; ANIMALS; AZOLES; BARYONS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CLEARANCE; DRUGS; ELEMENTARY PARTICLES; FERMIONS; HADRONS; HETEROCYCLIC COMPOUNDS; IMIDAZOLES; IMINES; INJURIES; MAMMALS; MATERIALS; NUCLEONS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIATION EFFECTS; RODENTS; VERTEBRATES; WASTES 560152* -- Radiation Effects on Animals-- Animals