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Title: Myocardial perfusion with rubidium-82. III. Theory relating severity of coronary stenosis to perfusion deficit

Abstract

The relation between the quantitative perfusion deficit, as measured by emission computerized tomography, and the severity of coronary artery stenosis is important for the noninvasive clinical evaluation of coronary artery disease in man. Positron emission tomography allows direct noninvasive measurement of myocardial perfusion and quantification of the size of the perfusion defect. Given this important imformation, a mathematical model has been derived to gauge the severity of a coronary stenosis from quantitative perfusion measurements in the normal and poststenotic regions of the heart. The theoretical basis is presented for relating regional myocardial perfusion and regional perfusion resistance to total, coronary blood flow and resistance at normal resting flow and during maximal coronary vasodilation. The concept of perfusion reserve is presented as a clinical measure of the severity of a stenosis.

Authors:
Publication Date:
Research Org.:
Univ. of Texas Health Science Center, Houston
OSTI Identifier:
6153545
Resource Type:
Journal Article
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 25:11
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD FLOW; MATHEMATICAL MODELS; MYOCARDIUM; POSITRON COMPUTED TOMOGRAPHY; VASCULAR DISEASES; DIAGNOSIS; CORONARIES; ISCHEMIA; PERFUSED TISSUES; RUBIDIUM 82; ALKALI METAL ISOTOPES; ANIMAL TISSUES; ARTERIES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HEART; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; MINUTES LIVING RADIOISOTOPES; MUSCLES; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; RUBIDIUM ISOTOPES; TISSUES; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Mullani, N A. Myocardial perfusion with rubidium-82. III. Theory relating severity of coronary stenosis to perfusion deficit. United States: N. p., 1984. Web.
Mullani, N A. Myocardial perfusion with rubidium-82. III. Theory relating severity of coronary stenosis to perfusion deficit. United States.
Mullani, N A. 1984. "Myocardial perfusion with rubidium-82. III. Theory relating severity of coronary stenosis to perfusion deficit". United States.
@article{osti_6153545,
title = {Myocardial perfusion with rubidium-82. III. Theory relating severity of coronary stenosis to perfusion deficit},
author = {Mullani, N A},
abstractNote = {The relation between the quantitative perfusion deficit, as measured by emission computerized tomography, and the severity of coronary artery stenosis is important for the noninvasive clinical evaluation of coronary artery disease in man. Positron emission tomography allows direct noninvasive measurement of myocardial perfusion and quantification of the size of the perfusion defect. Given this important imformation, a mathematical model has been derived to gauge the severity of a coronary stenosis from quantitative perfusion measurements in the normal and poststenotic regions of the heart. The theoretical basis is presented for relating regional myocardial perfusion and regional perfusion resistance to total, coronary blood flow and resistance at normal resting flow and during maximal coronary vasodilation. The concept of perfusion reserve is presented as a clinical measure of the severity of a stenosis.},
doi = {},
url = {https://www.osti.gov/biblio/6153545}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 25:11,
place = {United States},
year = {Thu Nov 01 00:00:00 EST 1984},
month = {Thu Nov 01 00:00:00 EST 1984}
}