CD8 sup + T lymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immunodeficiency virus-specific cytotoxicity

Journal Article · Fri Jun 01 00:00:00 EDT 1990 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.87.12.4818· OSTI ID:6151628

Pantaleo, G; De Maria, A; Koenig, S; Butini, L; Moss, B; Lane, H C; Fauci, A S ^[1]; Baseler, M ^[2]

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1. National Institutes of Health, Bethesda, MD (USA)
2. Program Resources, Incorporated, Frederick, MD (USA)

In this study, the authors have investigated the potential mechanisms responsible for the loss of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic activity in the advanced stages of HIV-1 infection. They have demonstrated that HIV-1-specific cytotoxic T lymphocytes are predominantly contained within the CD8{sup +}DR{sup +} subset. Furthermore, they have shown by a redirected killing assay that there is a dichotomy between HIV-1-specific cytolytic activity and broad cytolytic potential since the cytolytic machinery of CD8{sup +}DR{sup +} cells is still functioning even in patients with AIDS who have lost their HIV-1-specific cytolytic activity. In addition, by comparative analysis of these two types of cytolytic activity over time they have demonstrated a progressive loss of HIV-1-specific cytolytic activity in the advanced stages of the disease, whereas the cytolytic potential remained unchanged regardless of the clinical stage. On the basis of these results, they propose that the loss of HIV-1-specific cytolytic activity in HIV-1-infected individuals may result at least in part from a progressive decrease in the pool of HIV-1-specific cytotoxic T lymphocytes belonging to the CD8{sup +}DR{sup +} subset whose ability to expand has been impaired.

• OSTI ID: 6151628
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 87:12; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AIDS VIRUS
MOLECULAR BIOLOGY
LYMPHOCYTES
CELL KILLING
CELL PROLIFERATION
CHROMIUM 51
HISTOCOMPATIBILITY COMPLEX
MONOCLONAL ANTIBODIES
RADIOASSAY
THYMIDINE
TRITIUM COMPOUNDS
ANIMAL CELLS
ANTIBODIES
ANTIGENS
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LEUKOCYTES
MATERIALS
MICROORGANISMS
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PYRIMIDINES
RADIOISOTOPES
RIBOSIDES
SOMATIC CELLS
VIRUSES
550201* - Biochemistry- Tracer Techniques