Behavioral consequences of chelator administration in acute cadmium toxicity (journal version)

Technical Report · Fri Jan 01 00:00:00 EST 1988

OSTI ID:6148600

Peele, D B; Farmer, J D; MacPhail, R C

The conditioned flavor-aversion paradigm was used to assess the toxicity of acutely administered cadmium and the interaction of cadmium with the heavy-metal chelating agents dimercaprol (BAL) and dimercaptosuccinic acid (DMSA). Shortly after consuming saccharin, rats received cadmium either alone or in combination with BAL or DMSA. When compared to rats receiving either nothing or the vehicle, rats receiving cadmium displayed significant reductions in saccharin preference (i.e., conditioned flavor aversions). BAL and DMSA were also capable of producing conditioned flavor aversions when given alone. Rats receiving cadmium in combination with either BAL or DMSA displayed significant, but not complete, attenuations of conditioned flavor aversions when compared to rats receiving cadmium alone. Chelator-induced blockade of cadmium-induced flavor-aversion conditioning was not obtained when BAL or DMSA administration was delayed by 4 hrs.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
• OSTI ID: 6148600
• Report Number(s): PB-89-143713/XAB; EPA-600/J-88/262
• Resource Relation: Other Information: Pub. in Fundamental and Applied Toxicology, Vol. 11, 416-428(1988)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CADMIUM
TOXICITY
CHELATING AGENTS
BIOASSAY
FLAVOR
RATS
SACCHARIN
ANIMALS
AZOLES
ELEMENTS
HETEROCYCLIC COMPOUNDS
MAMMALS
METALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANOLEPTIC PROPERTIES
RODENTS
THIAZOLES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology