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Title: PET imaging of cerebral perfusion and oxygen consumption in acute ischemic stroke: Relation to outcome

Abstract

The authors used positron emission tomography (PET) to assess the relation between combined imaging of cerebral blood flow and oxygen consumption 5-18 h after first middle cerebral artery (MCA) stroke and neurological outcome at 2 months. All 18 patients could be classified into three visually defined PET patterns of perfusion and oxygen consumption changes. Pattern 1 suggested extensive irreversible damage and was consistently associated with poor outcome. Pattern 2 suggested continuing ischemia and was associated with variable outcome. Pattern 3 with hyperperfusion and little or no metabolic alteration, was associated with excellent recovery, which suggests that early reperfusion is beneficial. This relation between PET and outcome was highly significant. The results suggest that within 5-18 h of stroke onset, PET is a good predictor of outcome in patterns 1 and 3, for which therapy seems limited. The absence of predictive value for pattern 2 suggests that it is due to a reversible ischemic state that is possibly amenable to therapy. These findings may have important implications for acute MCA stroke management and for patients' selection for therapeutic trials.

Authors:
; ; ; ; ; ; ; ; ; ;
Publication Date:
OSTI Identifier:
6147821
Resource Type:
Journal Article
Journal Name:
Lancet; (United States)
Additional Journal Information:
Journal Volume: 341:8850; Journal ID: ISSN 0099-5355
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; POSITRON COMPUTED TOMOGRAPHY; ISCHEMIA; DIAGNOSIS; BLOOD FLOW; OXYGEN; PATIENTS; PERFUSED ORGANS; ANEMIAS; BODY; CARDIOVASCULAR DISEASES; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; ELEMENTS; EMISSION COMPUTED TOMOGRAPHY; HEMIC DISEASES; NERVOUS SYSTEM; NONMETALS; ORGANS; SYMPTOMS; TOMOGRAPHY; VASCULAR DISEASES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Marchal, G, Serrati, C, Rioux, P, Petit-Taboue, M C, Viader, F, Sayette, V de la, Doze, F le, Lonchon, P, Derlon, J M, Orgogozo, J M, and Baron, J C. PET imaging of cerebral perfusion and oxygen consumption in acute ischemic stroke: Relation to outcome. United States: N. p., 1993. Web. doi:10.1016/0140-6736(93)91214-7.
Marchal, G, Serrati, C, Rioux, P, Petit-Taboue, M C, Viader, F, Sayette, V de la, Doze, F le, Lonchon, P, Derlon, J M, Orgogozo, J M, & Baron, J C. PET imaging of cerebral perfusion and oxygen consumption in acute ischemic stroke: Relation to outcome. United States. https://doi.org/10.1016/0140-6736(93)91214-7
Marchal, G, Serrati, C, Rioux, P, Petit-Taboue, M C, Viader, F, Sayette, V de la, Doze, F le, Lonchon, P, Derlon, J M, Orgogozo, J M, and Baron, J C. 1993. "PET imaging of cerebral perfusion and oxygen consumption in acute ischemic stroke: Relation to outcome". United States. https://doi.org/10.1016/0140-6736(93)91214-7.
@article{osti_6147821,
title = {PET imaging of cerebral perfusion and oxygen consumption in acute ischemic stroke: Relation to outcome},
author = {Marchal, G and Serrati, C and Rioux, P and Petit-Taboue, M C and Viader, F and Sayette, V de la and Doze, F le and Lonchon, P and Derlon, J M and Orgogozo, J M and Baron, J C},
abstractNote = {The authors used positron emission tomography (PET) to assess the relation between combined imaging of cerebral blood flow and oxygen consumption 5-18 h after first middle cerebral artery (MCA) stroke and neurological outcome at 2 months. All 18 patients could be classified into three visually defined PET patterns of perfusion and oxygen consumption changes. Pattern 1 suggested extensive irreversible damage and was consistently associated with poor outcome. Pattern 2 suggested continuing ischemia and was associated with variable outcome. Pattern 3 with hyperperfusion and little or no metabolic alteration, was associated with excellent recovery, which suggests that early reperfusion is beneficial. This relation between PET and outcome was highly significant. The results suggest that within 5-18 h of stroke onset, PET is a good predictor of outcome in patterns 1 and 3, for which therapy seems limited. The absence of predictive value for pattern 2 suggests that it is due to a reversible ischemic state that is possibly amenable to therapy. These findings may have important implications for acute MCA stroke management and for patients' selection for therapeutic trials.},
doi = {10.1016/0140-6736(93)91214-7},
url = {https://www.osti.gov/biblio/6147821}, journal = {Lancet; (United States)},
issn = {0099-5355},
number = ,
volume = 341:8850,
place = {United States},
year = {Sat Apr 10 00:00:00 EDT 1993},
month = {Sat Apr 10 00:00:00 EDT 1993}
}