Changes in brain monoamine levels and monoamine oxidase activity in the catfish, Clarias batrachus, during chronic treatments with mercurials
- Banaras Hindu Univ., Varanasi (India)
In mammals, the central nervous system is the primary target for CH{sub 3}Hg poisoning which is clinically known as Minamata disease. Hg is a widely recognized neurotoxin and has been reported to impair brain monoamine neurotransmitter metabolism. Reports on effects of Hg on brain monoamine activity in fishes are scarce. In the present study, therefore, changes in the brain monoamine levels and the degradation enzyme, monoamine oxidase (MAO), are described in the catfish, Clarias batrachus, exposed to sublethal concentrations of mercuric chloride (HgCl{sub 2}-inorganic Hg), methylmercuric chloride (CH{sub 3}HgCl-organic Hg), and a commercial mercurial fungicide formulation, emisan 6 (methoxyethyl Hg-organic Hg) for 45, 90 and 180 d during gonadal recrudescence. These intervals correspond to late preparatory, prespawning and spawning phases, respectively, of the annual reproductive cycle of the catfish.
- OSTI ID:
- 6106832
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (USA), Vol. 45:1; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
AMINE OXIDASES
ENZYME ACTIVITY
BRAIN
MERCURY CHLORIDES
BIOLOGICAL EFFECTS
ORGANIC MERCURY COMPOUNDS
AMINES
CARBON 14 COMPOUNDS
CHRONIC EXPOSURE
DOPAMINE
GONADS
METHYLMERCURY
NORADRENALINE
TRACER TECHNIQUES
TRYPTAMINES
ADRENAL HORMONES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
DRUGS
ENZYMES
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MERCURY COMPOUNDS
MERCURY HALIDES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PHENOLS
POLYPHENOLS
PYRROLES
SYMPATHOMIMETICS
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques