Novel methods for the estimation of acceptable daily intake

Journal Article · Sun Dec 01 00:00:00 EST 1985 · Toxicol. Ind. Health; (United States)

DOI:https://doi.org/10.1177/074823378500100404· OSTI ID:6068185

Dourson, M L; Hertzberg, R C; Hartung, R; Blackburn, K

This paper describes two general methods for estimating ADIs that circumvent some of the limitations inherent in current approaches. The first method is based on a graphic presentation of toxicity data and is also shown to be useful for estimating acceptable intakes for durations of toxicant exposure other than the entire lifetime. The second method uses dose-response or dose-effect data to calculate lower CLs on the dose rate associated with specified response or effect levels. These approaches should lead to firmer, better established ADIs through increased use of the entire spectrum of toxicity data.

• Research Organization: Environmental Protection Agency, Cincinnati, OH
• OSTI ID: 6068185
• Journal Information: Toxicol. Ind. Health; (United States), Vol. 1:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MAXIMUM PERMISSIBLE INTAKE
CALCULATION METHODS
DOSE-RESPONSE RELATIONSHIPS
HEALTH HAZARDS
MAN
STATISTICS
TOXICITY
ANIMALS
HAZARDS
MAMMALS
MATHEMATICS
PRIMATES
SAFETY STANDARDS
STANDARDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology