Energy and Technology Review

Technical Report · Sat Apr 01 00:00:00 EST 1989

DOI:https://doi.org/10.2172/6030024· OSTI ID:6030024

Poggio, A. J.; Mayall, B. H. ^[1]

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1. eds.

The Lawrence Livermore National Laboratory (LLNL) is an acknowledged world center for analytical cytology. This leadership was recognized by the Regents of the University of California (UC), who in 1982 established and funded the Program for Analytical Cytology to facilitate the transfer of this technology from scientists at LLNL to their University colleagues, primarily through innovative collaborative research. This issue of Energy and Technology Review describes three of the forty projects that have been funded in this way; chosen to illustrate the potential medical application of the research. Analytical cytology is a relatively new field of biomedical research that is increasingly being applied in clinical medicine. It has been particularly important in unraveling the complexities of the human immune system and in quantifying the pathobiology of malignancy. Defined as the characterization and measurement of cells and cellular constituents for biological and medical purposes, analytical cytology bridges the gap between the quantitative discipline of molecular biology and the more qualitative disciplines of anatomy and pathology. It is itself multidisciplinary in nature. Two major approaches to analytical cytology are flow cytometry and image cytometry. In each of these research techniques, cells are measured one at a time in an automated device. In flow instruments, the cells are dispersed in fluid suspension and pass in single file through a beam of laser light to generate optical signals that are measured. In image cytometry, cells are dispersed on a slide and are imaged through a microscope onto an electronic imaging and analysis system that processes the cell image to extract measurements of interest.

• Research Organization: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 6030024
• Report Number(s): UCRL-52000-89-4; ON: DE89013919
• Resource Relation: Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LAWRENCE LIVERMORE LABORATORY
RESEARCH PROGRAMS
MUTATIONS
BIOASSAY
ANIMAL CELLS
BIOCHEMISTRY
CYTOCHEMISTRY
CYTOLOGICAL TECHNIQUES
ERYTHROCYTES
EXPERT SYSTEMS
GLYCOPROTEINS
GROWTH
NEOPLASMS
REVIEWS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMISTRY
DISEASES
DOCUMENT TYPES
MATERIALS
NATIONAL ORGANIZATIONS
ORGANIC COMPOUNDS
PROTEINS
US AEC
US DOE
US ERDA
US ORGANIZATIONS
550300* - Cytology