Involvement of chromosome X in primary cytogenetic change in human neoplasia: nonrandom translocation in synovial sarcoma

Journal Article · Wed Apr 01 00:00:00 EST 1987 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.84.7.1981· OSTI ID:6027084

Turc-Carel, C; Cin, P D; Limon, J; Rao, U; Li, F P; Corson, J M; Zimmerman, R; Parry, D M; Cowan, J M; Sandberg, A A

A translocation that involves chromosome X (band p11.2) and chromosome 18 (band q11.2) was observed in short-term in vitro cultures of cells from five synovial sarcomas and one malignant fibrous histiocytoma. In four of these tumors, the translocation t(X;18)(p11.2;q11.2) was reciprocal. The two other tumors had complex translocations: t(X;18;21)(p11.2;q11.2;p13) and t(X;15;18)(p11.2;q23;q11.2). A translocation between chromosomes X and 18 was not detected in other histological types of soft tissue sarcoma. The X;18 rearrangement appears to characterize the synovial sarcoma and is the first description of a primary, nonrandom change in the sex chromosome of a human solid tumor.

• Research Organization: Roswell Park Memorial Institute, Buffalo, NY
• OSTI ID: 6027084
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 84:7
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
SARCOMAS
GENETICS
X CHROMOSOME
CHROMOSOMAL ABERRATIONS
CYTOLOGY
HISTOLOGY
IN VITRO
KARYOTYPE
MAN
PATIENTS
ANIMALS
BIOLOGY
CHROMOSOMES
DISEASES
HETEROCHROMOSOMES
MAMMALS
MUTATIONS
NEOPLASMS
PRIMATES
VERTEBRATES
550400* - Genetics