Human lymphocyte Fe receptor for IgE: sequence homology of its cloned cDNA with animal lectins
The authors have purified the human lymphocyte Fc receptor specific for IgE (Fcepsilon receptor) and its soluble form by using the anti-Fcepsilon receptor monoclonal antibody H107. Using an oligonucleotide probe corresponding to the partial amino acid sequence of the soluble Fcepsilon receptor related to IgE binding factor, they cloned, sequenced, and expressed a cDNA for the receptor. The Fcepsilon receptor has 321 amino acid residues with no NH/sub 2/-terminal signal sequence. The receptor was separated into two domains by a putative 24-amino acid residue transmembrane region located near the NH/sub 2/-terminal end. The Fcepsilon receptor showed a marked homology with animal lectins including human and rat asialoglycoprotein receptors, chicken hepatic lectin, and rat mannose binding proteins.
- Research Organization:
- Kyoto Univ. Medical School, Japan
- OSTI ID:
- 6022920
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 84:3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Molecular cloning of a human macrophage lectin specific for galactose
Extensive amino acid sequence homologies between animal lectins
Related Subjects
LECTINS
DNA SEQUENCING
RECEPTORS
AMINO ACID SEQUENCE
DNA-CLONING
ELECTROPHORESIS
FLUORESCENCE
GLUCOPROTEINS
IMMUNOGLOBULINS
LYMPHOCYTES
MONOCLONAL ANTIBODIES
PHOSPHORUS 32
RECOMBINANT DNA
ANIMAL CELLS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CLONING
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DNA
GLOBULINS
ISOTOPES
LEUKOCYTES
LIGHT NUCLEI
LUMINESCENCE
MATERIALS
MEMBRANE PROTEINS
MOLECULAR STRUCTURE
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHOSPHORUS ISOTOPES
PROTEINS
RADIOISOTOPES
SACCHARIDES
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
550201* - Biochemistry- Tracer Techniques