Radioiodine uptake following iodine-131 therapy for Graves' disease: an early indicator of need for retreatment

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Clin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1097/00003072-198901000-00005· OSTI ID:6022366

Carpentier, W R; Gilliland, P F; Piziak, V K; Petty, F C; McConnell, B G; Verdonk, C A; Ibarra, J D; Thompson, J Q

Forty-five patients with Graves' disease were studied prospectively to determine if 24-hour I-131 uptake measurements alone or in combination with serum thyroid hormone levels at six weeks would determine the necessity for retreatment of the thyrotoxicosis. All patients with an I-131 uptake greater than 30% at six weeks required retreatment. No patient with an I-131 uptake of less than 15% required retreatment. Patients with uptakes between 15% and 30% were variable. An elevated free thyroxin index at 6 weeks is not helpful to determine which patients will remain thyrotoxic. Patients with a free thyroxin index within the normal range at six weeks can be predicted to be euthyroid by 12 weeks if their 24-hour I-131 uptake is between 15% and 30% and to be hypothyroid if their 24-hour I-131 uptake is below 15%. There was no difference between patient groups treated initially with antithyroid medication and those who were not.

• Research Organization: Scott and White Clinic, Temple, TX (USA)
• OSTI ID: 6022366
• Journal Information: Clin. Nucl. Med.; (United States), Vol. 14:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ENDOCRINE DISEASES
RADIOTHERAPY
IODINE 131
UPTAKE
THYROID
RADIONUCLIDE KINETICS
PATIENTS
THYROXINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
RADIOISOTOPES
RADIOLOGY
THERAPY
THYROID HORMONES
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man