Synergism of herpes simplex virus and tobacco-specific N'-nitrosamines in cell transformation

Journal Article · Fri Mar 01 00:00:00 EST 1991 · Journal of Oral and Maxillofacial Surgery; (USA)

DOI:https://doi.org/10.1016/0278-2391(91)90220-G· OSTI ID:6005090

Park, N H; Dokko, H; Li, S L; Cherrick, H M ^[1]

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1. UCLA School of Dentistry (USA)

Previous studies indicate that herpes simplex virus (HSV) enhances the carcinogenic activity of smokeless tobacco and tobacco-related chemical carcinogens in animals. Since tobacco-specific N'-nitrosamines (TSNAs) such as N'-nitrosonornicotine (NNN) and 4-(N-methyl-N'-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are major chemical carcinogens of smokeless tobacco and are known to be responsible for the development of oral cancers in smokeless tobacco users, the combined effects of TSNAs and HSV in cell transformation were investigated. Exposure of cells to NNN or NNK followed by virus infection resulted in a significant enhancement of transformation frequency when compared with that observed with chemical carcinogens or virus alone. This study suggests that TSNAs and HSV can interact together and show synergism in cell transformation.

• OSTI ID: 6005090
• Journal Information: Journal of Oral and Maxillofacial Surgery; (USA), Vol. 49:3; ISSN 0278-2391
• Country of Publication: United States
• Language: English

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