Mutagenicity tobacco snuff: possible health implications for coal miners

Journal Article · Sun Jan 01 00:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530600· OSTI ID:6004043

Whong, W Z; Ames, R G; Ong, T

Mutagenicity of tobacco snuff extracts was studied using the Ames Salmonella/microsome assay system. No mutagenic activity was found for tobacco snuff extracts without S9 activation. However, mutagenic substances were formed from tobacco snuff extracts in an acidic environment. The mutagenic substances induced predominantly frameshift mutations and were direct-acting mutagens. Mutagenic activity of tobacco snuff extracts was enhanced in the presence of coal-dust extracts at low pH. Since tobacco snuff has been used by some coal miners to substitute for cigarettes, a possible risk for gastric cancer induction among coal miners is proposed.

• Research Organization: National Inst. for Occupational Safety and Health, Morgantown, WV
• OSTI ID: 6004043
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 14:4
• Country of Publication: United States
• Language: English

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NEOPLASMS
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STOMACH
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MICROORGANISMS
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