Tl-201 brain scans: A comparative study with pathologic correlation
Since the clinical expression of brain tumors is dependent on anatomic location, following the response to therapy can be difficult. In patients (pts.) with gliomas who were stable or improving, the authors noted a disparity between an improving clinical status and stable CT scans. To elucidate this finding, 29 pts. were sequentially scanned with 2.0 mCi Tl-201 (at 5-30 min), 20 mCi Tc-99m glucoheptonate (GH) (at 3-4 h) and 7-10 mCi Ga-67 (at 48-72 h). A total of 198 images (300K each) were obtained. A set of 3 scans at a midpoint in follow-up was selected for analysis. Seven pts. who died had neuropathologic data available; brain sections were reconstructed to match radionuclide (RN) views without knowledge of image results. The authors conclude that Tl-201 scans; more accurately reflect viable tumor burden than other RN studies of brain tumors; are not effected by concommitant steroid administration; can be performed immediately following tracer administration; and compliment the anatomic data obtained from CT scans.
- Research Organization:
- Depts. of Radiology, Medical Oncology and Pathology, Dana-Farber Cancer Institute, Boston, MA
- OSTI ID:
- 5958500
- Report Number(s):
- CONF-850611-; TRN: 87-039540
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BRAIN
ANATOMY
CAT SCANNING
NEOPLASMS
GLUCOHEPTONATE
DIAGNOSTIC USES
LABELLING
DIAGNOSIS
THALLIUM 201
ACCURACY
COMPARATIVE EVALUATIONS
GALLIUM 67
RADIONUCLIDE ADMINISTRATION
TECHNETIUM 99
TISSUE DISTRIBUTION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID ESTERS
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
GALLIUM ISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
TECHNETIUM ISOTOPES
THALLIUM ISOTOPES
TOMOGRAPHY
USES
YEARS LIVING RADIOISOTOPES
550602* - Medicine- External Radiation in Diagnostics- (1980-)
550801 - Morphology- Tracer Techniques
550601 - Medicine- Unsealed Radionuclides in Diagnostics