Specific antibodies to porcine zona pellucida detected by quantitative radioimmunoassay in both fertile and infertile women

Journal Article · Wed Feb 01 00:00:00 EST 1984 · Fert. Steril.; (United States)

OSTI ID:5880615

Kurachi, H; Wakimoto, H; Sakumoto, T; Aono, T; Kurachi, K

The specific radioimmunoassay system was developed for the titration of the antibodies to porcine zona pellucida (ZP) in human sera by using /sup 125/I-labeled purified porcine ZP as antigen, which is known to have cross-reactivity with human ZP. The antibodies in human sera were detected in 3 of 11 (27%) women with unexplained infertility, in 16 of 48 (33%) amenorrheic patients, in 4 of 12 (33%) fertile women, and in 3 of 10 (30%) men. Moreover, antibody titers in infertile women were no higher than those in fertile women and in men. These results seem to suggest that the antibodies in human sera that cross-react with porcine ZP may not be an important factor in causing infertility in women.

• Research Organization: Osaka Univ. Medical School, Japan
• OSTI ID: 5880615
• Journal Information: Fert. Steril.; (United States), Vol. 41:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
BLOOD SERUM
RADIOIMMUNOASSAY
REPRODUCTIVE DISORDERS
DIAGNOSIS
ANTIGEN-ANTIBODY REACTIONS
FERTILITY
GLUCOPROTEINS
IODINE 125
MEN
PATIENTS
WOMEN
ANIMALS
BETA DECAY RADIOISOTOPES
CARBOHYDRATES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
FEMALES
IMMUNOASSAY
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MALES
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
RADIOISOTOPES
SACCHARIDES
TRACER TECHNIQUES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques