Interstitial microwave hyperthermia combined with iridium-192 radiotherapy for recurrent tumors
From 1985 through 1987, 44 tumors in 39 patients with recurrent cancer were treated with interstitial microwave hyperthermia (HT) combined with interstitial /sup 192/Ir radiotherapy (RT). All patients had unresectable and previously treated tumors (mean RT dose 57.6 Gy). Diagnoses were squamous cell carcinoma in 27 (62%), adenocarcinoma in 11 (25%), melanoma in 5 (11%), and soft tissue sarcoma in 1 (2%) site. Interstitial RT dose was from 25 to 50 Gy (mean 38.3 Gy). The first HT session was scheduled immediately before the loading of /sup 192/Ir, and the second was scheduled following its removal. Each session lasted 45-60 min at therapeutic temperature (42.5 degrees C). Complete response (CR) was obtained in 28 (64%) sites and partial response (PR) in 15 (34%) sites. None of the CR patients had local recurrence. Tumor volume was the most important factor influencing CR (p less than 0.001). The treated site, radiation dose, and thermal dose were not significant factors for CR (p = 0.03). The overall median survival was 39 weeks, with a 2-year survival of 22%. The treatment was well tolerated, with two patients developing focal skin necrosis.
- Research Organization:
- Univ. of Southern California School of Medicine, Los Angeles (USA)
- OSTI ID:
- 5876315
- Journal Information:
- Am. J. Clin. Oncol.; (United States), Vol. 12:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOMAS
RADIOTHERAPY
MELANOMAS
MICROWAVE RADIATION
BIOLOGICAL EFFECTS
SARCOMAS
HYPERTHERMIA
IRIDIUM 192
PATIENTS
RADIATION DOSES
SURVIVAL CURVES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY TEMPERATURE
DAYS LIVING RADIOISOTOPES
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRIDIUM ISOTOPES
ISOMERIC TRANSITION
ISOTOPES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
RADIATIONS
RADIOISOTOPES
RADIOLOGY
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560400 - Other Environmental Pollutant Effects
550600 - Medicine