The effect of cyclophosphamide and gamma irradiation on adenosine deaminase and purine nucleoside phosphorylase in mice
- Czechoslovak Academy of Sciences, Brno (Czechoslovakia)
Changes in ADA and PNP activities in the spleens and thymuses of mice were studied after a single administration of cyclophosphamide and after whole-body gamma irradiation, applied alone or three days after CY application, In the first days after the treatment the enzyme activities were significantly depressed with the exception of ADA in the spleen, where a high elevation in relation to controls was observed. During the regeneration period a pronounced rise of PNP activity in the spleen occurred mainly after a combined application of CY and irradiation. In the thymus the regeneration was manifested by a mild increase of both ADA and PNP activities towards control values. The findings suggest that the expressive changes of ADA and PNP activities, participating in the purine salvage pathway, may, after a cytotoxic treatment, influence the nucleotide pool and DNA synthesis in lymphoid organs.
- OSTI ID:
- 5863986
- Journal Information:
- Life Sciences; (United States), Vol. 49:19; ISSN 0024-3205
- Country of Publication:
- United States
- Language:
- English
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ANTINEOPLASTIC DRUGS
RADIOSENSITIVITY EFFECTS
HYDROLASES
ENZYME ACTIVITY
PHOSPHOTRANSFERASES
SPLEEN
BIOLOGICAL RADIATION EFFECTS
THYMUS
GAMMA RADIATION
MICE
WHOLE-BODY IRRADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
LYMPHATIC SYSTEM
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RODENTS
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VERTEBRATES
560152* - Radiation Effects on Animals- Animals