Interaction of chelating agents with cadmium in mice and rats

Journal Article · Thu Mar 01 00:00:00 EST 1984 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8454267· OSTI ID:5853184

Eybl, V; Sykora, J; Koutensky, J; Caisova, D; Schwartz, A; Mertl, F

The influence of several chelating agents (CaDTPA, ZnDTPA, CaEDTA, ZnEDTA, DMSA, D-penicillamine and DMPS, DMP and DDC) on the acute toxicity of CdCl/sub 2/ and on the whole body retention and tissue distribution of cadmium after the IV application of /sup 115mCdCl/sub 2/ was compared in mice. The chelating agents were applied immediately after the application of cadmium. CaDTPA, ZnDTPA and DMSA appeared to be the most effective antidotes. However, DMSA increased the amount of cadmium retained in kidneys. The treatement of cadmium-poisoned mice with the combination of DMSA (IP) and ZnDTPA (SC) (all the compounds were injected in equimolar dose) decreased the toxicity of cadmium more than treatment with one chelating agents (given in a 2:1 dose). However, by studying the effect of these chelating agents and their combination application of the antidotes showed little or no improvement over the results obtained with the most effective of the individual components. In the urine of rats injected with CdCl/sub 2/ and treated with the chelating agents (CaDTPA, ZnDTPA, DMSA), the presence of cadmium complexes was demonstrated. The formation of mixed ligand chelates in vivo was not proved. Experiments in mice given a single injection of /sup 115m/Cd-labeled Cd complexes of DMPS, DMSA and DTPA showed a high retention of cadmium in the organisms after the IV application of CdDMPS and CdDMSA complexes.

• Research Organization: Charles Univ. Faculty of Medicine, Pilsen, Czechoslovakia
• OSTI ID: 5853184
• Journal Information: Environ. Health Perspect.; (United States), Vol. 54
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
METABOLISM
CADMIUM 115
TISSUE DISTRIBUTION
CADMIUM CHLORIDES
TOXICITY
CHELATING AGENTS
BIOLOGICAL EFFECTS
CADMIUM COMPLEXES
COMPARATIVE EVALUATIONS
DTPA
EDTA
EXPERIMENTAL DATA
ISOMERIC NUCLEI
KIDNEYS
MICE
PENICILLAMINE
RATS
RETENTION
TRACER TECHNIQUES
URINE
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM ISOTOPES
CARBOXYLIC ACIDS
CHLORIDES
CHLORINE COMPOUNDS
COMPLEXES
DATA
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELEMENTS
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
METALS
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RODENTS
THIOLS
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)