Recovery of immune competence following sublethal X irradiation of young and old mice: a model for studying age-related loss of immunologic homeostasis
- VA Wadsworth Medical Center, Los Angeles, CA
Age-related alteration in lymphohematopoietic homeostasis was assessed kinetically by determining immunologic and stem-cell regenerating capacities of young (5-7 months), middle-aged (13 months), and old (23-24 months) C3H and C57BL/6 mice following their exposure to 500 R. Immunologic activities were based on the ability of spleen cells to respond to sheep erythrocytes, phytohemagglutinin, and bacterial lipopolysaccharide. Stem-cell activity was based on the ability of splenic and bone marrow cells to form colonies in vivo. Reflective of age-related homeostatic imbalance was alteration in the (a) time of recovery, (b) rate of regeneration, and (c) capacity of the regenerating system to overshoot the preirradition steady-state level. Most of the immunologic parameters showed a delay in the time of recovery in old mice. In contrast, the time of recovery of stem cells in old mice was equal to or faster than that in young mice. Furthermore, the magnitude of regeneration of stem cells was greater in old than young mice. These results suggest that recovery of immunologic activities in old mice is delayed partly because of the inability of their stem cells to rapidly generate immunocompetent progenies.
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5793528
- Journal Information:
- Radiat. Res.; (United States), Vol. 89:1
- Country of Publication:
- United States
- Language:
- English
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IMMUNE REACTIONS
BIOLOGICAL RADIATION EFFECTS
IMMUNITY
AGE DEPENDENCE
BIOLOGICAL MODELS
BIOLOGICAL RECOVERY
BONE MARROW CELLS
HOMEOSTASIS
MICE
SPLEEN CELLS
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
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RODENTS
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560152* - Radiation Effects on Animals- Animals