Sex hormone receptors in the hypothalamus and their role in sexual differentiation of the male rat brain
In this investigation, changes in the level of receptors for sex hormones in the hypothalamus and cerebral cortex of male rats were studied on the first through fifth days of postnatal life, and the results obtained were compared with the levels of luteinizing hormone and sex hormones in the peripheral blood in order to discover any correlation between these parameters. 2,4,6,7,-/sup 3/H-estradiol-17..beta.. and 1,2,6,7-/sup 3/H-testosterone were used as labeled hormones. The values of the association constant and concentration of specific binding sites for estradiol and testosterone in hypothalamus and cerebral cortex of male rats during neonatal development is shown. It is found that in male rats on the first day after birth, receptors for estradiol and testosterone are present and they enable the action both of the testicular hormone and that of estradiol to be realized.
- Research Organization:
- Institute of Experimental Endocrinology and Hormone Chemistry, Moscow, USSR
- OSTI ID:
- 5784864
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 101:4; Other Information: Translated from Byulleten' Ehksperimental'noj Biologii i Meditsiny; 101: No. 4, 484-486(Apr 1986)
- Country of Publication:
- United States
- Language:
- English
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ESTRADIOL
RECEPTORS
NERVE CELLS
CELL DIFFERENTIATION
METABOLIC ACTIVATION
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CEREBRAL CORTEX
HYPOTHALAMUS
SEX
TESTOSTERONE
AROMATIZATION
BINDING ENERGY
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
LABELLING
LH
METABOLISM
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TRITIUM COMPOUNDS
ANDROGENS
ANDROSTANES
ANIMAL CELLS
ANIMALS
BODY
BRAIN
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHEMICAL REACTIONS
ENERGY
ESTRANES
ESTROGENS
FUNCTIONS
GONADOTROPINS
HORMONES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KETONES
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
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