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Title: Busulfan and total body irradiation as antihematopoietic stem cell agents in the preparation of patients with congenital bone marrow disorders for allogenic bone marrow transplantation

The capacity of busulfan and total body irradiation to ablate hematopoietic stem cells as preparation for the allogeneic bone marrow transplantation of patients with congenital bone marrow disorders was studied. Fourteen patients received 18 transplants; busulfan was used in the preparatory regimen of eight transplants and total body irradiation in the regimens of six transplants. Sustained hematopoietic ablation was achieved in six of eight patients prepared with busulfan and in all six patients prepared with total body irradiation. Three patients prepared with total body irradiation died with idiopathic interstitial pneumonitis, whereas no patients receiving busulfan developed interstitial pneumonitis. The optimal antihematopoietic stem cell agent to be used for the preparation of patients with congenital bone marrow disorder for bone marrow transplantation is not certain.
Authors:
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Publication Date:
OSTI Identifier:
5777386
Resource Type:
Journal Article
Resource Relation:
Journal Name: Blood; (United States); Journal Volume: 64:4
Research Org:
Children's Hospital Medical Center, Boston, MA
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW; TRANSPLANTS; IMMUNOSUPPRESSION; RADIOINDUCTION; MYLERAN; RADIOSENSITIVITY EFFECTS; PATIENTS; PNEUMONITIS; STEM CELLS; WHOLE-BODY IRRADIATION; ALKYLATING AGENTS; ANIMAL CELLS; ANIMAL TISSUES; BODY; EXTERNAL IRRADIATION; HEMATOPOIETIC SYSTEM; IRRADIATION; ORGANS; SOMATIC CELLS; TISSUES 560151* -- Radiation Effects on Animals-- Man