Normal anti-Klebsiella lymphocytotoxicity in ankylosing spondylitis
We compared in vitro lymphocytotoxicity (LCT) of peripheral blood lymphocytes (PBL), obtained from patients with ankylosing spondylitis (AS) and normal controls (NC). Assays were performed with antibacterial antisera prepared from AS- and NC-derived Klebsiella and coliforms Escherichia coli. LCT assessed by eosin staining was not significantly different in PBL of 12 AS patients and 28 controls when reacted with 3 Klebsiella and 1 E coli antisera. LCT assessed by /sup 51/Cr release was not significantly different for PBL of 20 age- and sex-matched pairs of AS patients and NC when reacted with 3 Klebsiella and 1 E coli antisera. Similarly, LCT-/sup 51/Cr of PBL of 15 matched AS and NC pairs was not significantly different for anti-K21, a serotype putatively implicated in Klebsiella-HLA-B27 antigenic cross-reactivity. Our results do not support the notion of molecular mimicry between Klebsiella and B27 in the pathogenesis of primary AS.
- Research Organization:
- Univ. of Calgary, Alberta
- OSTI ID:
- 5739421
- Journal Information:
- Arthritis Rheum.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
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ESCHERICHIA COLI
KLEBSIELLA
PATIENTS
TRACER TECHNIQUES
ANIMAL CELLS
BACTERIA
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
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BODY FLUIDS
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CONNECTIVE TISSUE CELLS
DISEASES
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INTERMEDIATE MASS NUCLEI
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ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
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550901* - Pathology- Tracer Techniques