Analysis of the effects of increasing doses of ionizing radiation to the exteriorized rat ovary on follicular development, atresia, and serum gonadotropin levels

Journal Article · Sat Feb 01 00:00:00 EST 1986 · Am. J. Obstet. Gynecol.; (United States)

DOI:https://doi.org/10.1016/0002-9378(86)90661-7· OSTI ID:5730336

Jarrell, J; YoungLai, E V; Barr, R; O'Connell, G; Belbeck, L; McMahon, A

There is increasing interest in the effects of environmental and therapeutic agents on the reproductive system, in particular, the ovary. To study the effects of controlled doses of ionizing radiation to the ovary, Sprague-Dawley rats had their ovaries exteriorized and subjected to increasing doses of radiation. There was a significant increase in ovarian follicular atresia, a significant increase in serum follicle-stimulating hormone levels, but no change in serum luteinizing hormone levels. This experimental protocol may facilitate the testing putative radioprotectants.

• Research Organization: McMaster Univ., Hamilton, Ontario, Canada
• OSTI ID: 5730336
• Journal Information: Am. J. Obstet. Gynecol.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OVARIES
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
FSH
LH
RATS
ANIMALS
BIOLOGICAL EFFECTS
BODY
FEMALE GENITALS
GONADOTROPINS
GONADS
HORMONES
MAMMALS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals