Radiotherapy of nonfunctional adenomas of the pituitary gland. Results with long-term follow-up

Journal Article · Thu Jun 15 00:00:00 EDT 1989 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19890615)63:12<2409::AID-CNCR2820631206>3.0.CO;2-M· OSTI ID:5717750

Flickinger, J C; Nelson, P B; Martinez, A J; Deutsch, M; Taylor, F

A total of 112 patients with the diagnosis of nonfunctional pituitary adenoma received radiation therapy at the University of Pittsburgh between 1964 and 1987. Postoperative radiation therapy was administered in 87 patients. Actuarial progression-free survival (tumor control) at 5, 10, 15, and 20 years was 97%, 89%, 87%, and 76%, respectively. Radiation prescribed to the 95% isodose ranged from 35.72 Gy to 62.32 Gy. Multivariate analysis showed decreased tumor control to be significantly associated with increasing field size (P = .036). No improvement in tumor control could be detected with increasing total radiation dose or nominal standard dose (NSD). One patient developed optic neuropathy and another developed a glioblastoma after doses in both patients of 4750 cGy in 25 fractions. External beam radiotherapy for nonfunctional pituitary adenomas was found to be effective and safe when doses less than 4750 cGy in 25 fractions were used.

• Research Organization: Univ. of Pittsburgh School of Medicine, PA (USA)
• OSTI ID: 5717750
• Journal Information: Cancer (Philadelphia); (United States), Vol. 63:12
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ADENOMAS
RADIOTHERAPY
PITUITARY GLAND
FRACTIONATED IRRADIATION
MULTIVARIATE ANALYSIS
PATIENTS
RADIATION DOSES
RADIATION INJURIES
SURVIVAL CURVES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
DOSES
ENDOCRINE GLANDS
GLANDS
INJURIES
IRRADIATION
MATHEMATICS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
STATISTICS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)