Changes in erythrocyte sodium, sodium transport and /sup 3/H ouabain binding capacity during digoxin administration in the pig

Journal Article · Mon Feb 14 00:00:00 EST 1983 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(83)90308-9· OSTI ID:5707857

Whittaker, J; Hawkins, M; Swaminathan, R

Time course of the changes in erthrocyte sodium content, sodium transport, /sup 3/H ouabain binding capacity and Na/sup +/, K/sup +/-ATPase activity were measured for 14 weeks, in 6 young pigs treated with digoxin and in 6 control pigs. After one week of treatment the erythrocyte sodium content increased from 5.4 mmol/kg cells and the efflux rate constant of sodium decreased. With prolonged treatment the erythrocyte sodium content returned to normal and the /sup 3/H ouabain binding capacity increased by week 5. The plasma digoxin concentration decreased from 1.1 ng/ml at week 5 to 0.6 ng/ml at week 8 probably due to the decline in dose (..mu..g/kg) of digoxin with age. The efflux rate constant of sodium and Na/sup +/, K/sup +/-ATPase activity were higher towards the end of treatment. It is concluded that with prolonged administration of digoxin there is an increase in erythrocyte sodium pump units.

• Research Organization: Univ. of Leeds, England
• OSTI ID: 5707857
• Journal Information: Life Sci.; (United States), Vol. 32:7
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DIGOXIN
BIOLOGICAL EFFECTS
OUABAIN
BIOCHEMISTRY
SODIUM COMPOUNDS
MEMBRANE TRANSPORT
ATP-ASE
CATIONS
ERYTHROCYTES
SWINE
TRITIUM COMPOUNDS
ACID ANHYDRASES
ALKALI METAL COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHARGED PARTICLES
CHEMISTRY
DIGITALIS GLYCOSIDES
DOMESTIC ANIMALS
DRUGS
ENZYMES
GLYCOSIDES
HYDROLASES
IONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
PHOSPHOHYDROLASES
STROPHANTHINS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques