Biointeraction of sodium selenite and aflatoxin B/sub 1/ in the Mongolian gerbil
The interaction of sodium selenite (Na/sub 2/SeO/sub 3/) and aflatoxin B/sub 1/ (AFB/sub 1/) was studied in 6-wk-old male Mongolian gerbils. Each of four groups of gerbils were fed one of the following diets during a 12-wk experimental period: control (commercial Chow), 5.0 ppm Na/sub 2/SeO/sub 3/, 12.8 ppm AFB/sub 1/, or 5.0 ppm Na/sub 2/SeO/sub 3/ + 12.8 ppm AFB/sub 1/. Animals receiving Na/sub 2/SeO/sub 3/ in the diet, alone and with AFB/sub 1/, had a significantly lower mean total weight gain during the experiment than did control animals. Animals receiving both compounds together displayed a very high level of physical activity compared to the three other groups. Blood analysis showed no change in total leukocytes, but the relative percentage of lymphocytes increased and the percentage of neutrophils decreased concurrently in the order: control < AFB/sub 1/ < Na/sub 2/SeO/sub 3/ + AFB/sub 1/ < Na/sub 2/SeO/sub 3/. A significant reduction in organ weight relative to body weight was observed in the liver, kidney, and lung of the animals fed AFB/sub 1/ alone but only in the liver of those fed both Na/sub 2/SeO/sub 3/ and AFB/sub 1/. No similar alterations were observed in the Na/sub 2/SeO/sub 3/ group. Histopathological examination revealed considerably less hepatic damage in animals fed Na/sub 2/SeO/sub 3/ with AFB/sub 1/ than in those receiving either compound alone. Renal and intestinal damage, however, was most severe in this double-treatment group. Hepatic protein analysis revealed two protein peaks in the Na/sub 2/SeO/sub 3/ + AFB/sub 1/ group that were absent in all other groups. It was concluded that these proteins may be selenoproteins directly or indirectly involved in the lower incidence of histopathological damage in this group.
- Research Organization:
- Virginia Commonwealth Univ., Richmond
- OSTI ID:
- 5704919
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 8:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
SELENIUM COMPOUNDS
BIOLOGICAL EFFECTS
AFLATOXIN
BLOOD
GERBILS
GROWTH
KIDNEYS
LIVER
LUNGS
QUANTITATIVE CHEMICAL ANALYSIS
RESPONSE MODIFYING FACTORS
SODIUM COMPOUNDS
ALKALI METAL COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CHEMICAL ANALYSIS
DIGESTIVE SYSTEM
GLANDS
MAMMALS
MATERIALS
ORGANS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)