Blood to brain transport of interleukin links the immune and central nervous systems

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(91)90385-O· OSTI ID:5682010

Banks, W A; Kastin, A J ^[1]

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1. Dept. of Veterans Affairs, New Orleans, LA (USA) Tulane Univ. School of Medicine, New Orleans, LA (USA)

Interleukins (IL) are naturally occurring proteins that regulate, and thus link, both the immune system and the central nervous system (CNS). Since proteins are assumed not to be able to cross the blood-brain barrier (BBB), it is controversial how this linkage could occur. The authors show here that after iv injection of {sup 125}I-hIL-1{alpha}, radioactivity in the brain eluted on HPLC in the position of the labeled cytokine. In addition, entry was inhibited by unlabeled hIL-1{alpha}. The authors demonstration of a saturable, carrier-mediated system that transports recombinant human IL-1{alpha} in intact form from the blood into the CNS indicates a direct immune-CNS connection.

• OSTI ID: 5682010
• Journal Information: Life Sciences; (USA), Vol. 48:25; ISSN 0024-3205
• Country of Publication: United States
• Language: English

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LIQUID COLUMN CHROMATOGRAPHY
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551001* - Physiological Systems- Tracer Techniques