Pharmacokinetics and tissue distribution of parenterally administered human alpha-lymphotoxin in normal and meth-A tumor-bearing BALB/c mice
Journal Article
·
· Journal of Biological Response Modifiers; (USA)
OSTI ID:5668104
- Univ. of California, Irvine (USA)
These in vivo studies examine the pharmacokinetics of parenterally administered purified, native human alpha-lymphotoxin (LT) in normal and Meth-A bearing BALB/c mice. We found that the lytic activity of alpha-LT was inactivated within 5 h in the blood of both normal and tumor-bearing mice in vivo. However, LT bioactivity in vitro was not affected by incubation with fresh serum. Radioiodinated LT was rapidly sequestered in the kidneys of both normal and tumor-bearing animals. Systemically administered, radioiodinated LT did not selectively localize in tumor tissues.
- OSTI ID:
- 5668104
- Journal Information:
- Journal of Biological Response Modifiers; (USA), Vol. 8:4; ISSN 0732-6580
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:5668104
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
3-METHYLCHOLANTHRENE
TOXICITY
TOXINS
TISSUE DISTRIBUTION
ALBUMINS
EXPERIMENTAL NEOPLASMS
IN VITRO
IN VIVO
IODINE ISOTOPES
LABELLED COMPOUNDS
MAN
MICE
TRACER TECHNIQUES
ANIMALS
ANTIGENS
AROMATICS
DISTRIBUTION
HYDROCARBONS
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
PRIMATES
PROTEINS
RODENTS
TOXIC MATERIALS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
3-METHYLCHOLANTHRENE
TOXICITY
TOXINS
TISSUE DISTRIBUTION
ALBUMINS
EXPERIMENTAL NEOPLASMS
IN VITRO
IN VIVO
IODINE ISOTOPES
LABELLED COMPOUNDS
MAN
MICE
TRACER TECHNIQUES
ANIMALS
ANTIGENS
AROMATICS
DISTRIBUTION
HYDROCARBONS
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
PRIMATES
PROTEINS
RODENTS
TOXIC MATERIALS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques