Bone marrow origin of Ia-positive cells in the medulla rat thymus
Journal Article
·
· J. Exp. Med.; (United States)
Irradiated rats were reconstituted with bone marrow from F1 hybrids. Ia antigen of donor-bone marrow origin was detected by an immunoperoxidase technique on cryostat sections and found predominantly in the medulla of rat thymus 2 wk after reconstitution. These Ia-bearing cells increased in number with time after reconstitution, but the Ia on the cortical epithelial cells remained of host origin. The nature of the bone marrow-derived cells and their implication for major histocompatibility complex restriction are discussed.
- OSTI ID:
- 5657526
- Journal Information:
- J. Exp. Med.; (United States), Vol. 153:6
- Country of Publication:
- United States
- Language:
- English
Similar Records
Study on proliferative responses to host Ia antigens in allogeneic bone marrow chimera in mice: sequential analysis of the reactivity and characterization of the cells involved in the responses
Selection of restriction specificities of virus-specific cytotoxic T cells in the thymus: no evidence for a crucial role of antigen-presenting cells
Distinct fates of self-specific T cells developing in irradiation bone marrow chimeras: Clonal deletion, clonal anergy, or in vitro responsiveness to self-Mls-1a controlled by hemopoietic cells in the thymus
Journal Article
·
Thu Jan 01 00:00:00 EST 1987
· J. Immunol.; (United States)
·
OSTI ID:5657526
+6 more
Selection of restriction specificities of virus-specific cytotoxic T cells in the thymus: no evidence for a crucial role of antigen-presenting cells
Journal Article
·
Wed Dec 01 00:00:00 EST 1982
· J. Exp. Med.; (United States)
·
OSTI ID:5657526
Distinct fates of self-specific T cells developing in irradiation bone marrow chimeras: Clonal deletion, clonal anergy, or in vitro responsiveness to self-Mls-1a controlled by hemopoietic cells in the thymus
Journal Article
·
Thu Nov 01 00:00:00 EST 1990
· Journal of Experimental Medicine; (USA)
·
OSTI ID:5657526
+1 more
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIGENS
IMMUNOLOGY
BONE MARROW CELLS
CELL DIFFERENTIATION
BONE MARROW
PEROXIDASES
RADIATION CHIMERAS
RATS
THYMUS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CARBOXYLIC ACIDS
CHIMERAS
CONNECTIVE TISSUE CELLS
ENZYMES
HEMATOPOIETIC SYSTEM
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LYMPHATIC SYSTEM
MAMMALS
MOSAICISM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PORPHYRINS
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
ANTIGENS
IMMUNOLOGY
BONE MARROW CELLS
CELL DIFFERENTIATION
BONE MARROW
PEROXIDASES
RADIATION CHIMERAS
RATS
THYMUS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CARBOXYLIC ACIDS
CHIMERAS
CONNECTIVE TISSUE CELLS
ENZYMES
HEMATOPOIETIC SYSTEM
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LYMPHATIC SYSTEM
MAMMALS
MOSAICISM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PORPHYRINS
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology